what is anti-tpo?
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what is anti-tpo?
a kind of blood tests Best answer: the Anti-TPO Ab was historically referred to as the antimicrosomal antibody. The thyroid peroxidase enzyme (responsible for iodinating tyrosine residues in the thyroglobulin molecule) was subsequently identified as
a kind of blood tests
Best answer:
the Anti-TPO Ab was historically referred to as the antimicrosomal antibody. The thyroid peroxidase enzyme (responsible for iodinating tyrosine residues in the thyroglobulin molecule) was subsequently identified as the major microsomal component recognized by these autoantibodies. New, improved assays, designed in the wake of this insight, have been rapidly replacing the older antimicrosomal antibody assays.
Anti-TPO Abs mediate antibody-dependent thyroid cell destruction; levels correlate with the active phase of the disease. Measurement of this autoantibody is useful for resolving the diagnostic dilemma presented by the apparent inconsistency between elevated TSH and normal free T4 results. Given abnormally elevated TSH and euthyroid T4 results, a positive anti-TPO Ab test provides strong evidence for early, subclinical autoimmune disease. This assay is also used to monitor response to immunotherapy, to identify at-risk individuals (with family history of thyroid disease), and as a predictor of postpartum thyroiditis. Approximately 10 percent of asymptomatic individuals have elevated levels of Anti-TPO Ab, which may suggest a predisposition to thyroid autoimmune disease. Elevated levels are found in virtually all cases of Hashimoto
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